Multiple Lentigines Syndrome Complex (LEOPARD Syndrome) with Chiari I Malformation

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EYL Kan, IYC Wong, SPC Lau, WC Lee

Hong Kong J Radiol 2007;10:31-3

This report is of a patient with multiple lentigines syndrome complex (LEOPARD syndrome), a complex dysmorphogenetic disorder, with Chiari I malformation and hydrocephalus. In this patient, the cerebellar tonsillar descent was mild but craniovertebral dysplasia manifesting as shortened clivus, platybasia, and small posterior fossa was evident. This patient provides evidence for the possible existence of craniovertebral abnormality in this rare disease entity