Granulocytic Sarcoma with Severe Skin Involvement
R Koul, HI Chalchal, A Dubey
Hong Kong J Radiol 2010;13:96-100
Acute myelogenous leukaemia typically involves intramedullary proliferation of myeloid precursor cells. Extramedullary manifestations of acute myelogenous leukaemia are rare. Granulocytic sarcoma, or chloroma, is one example of extramedullary leukaemia cells forming a mass in any part of the body. This report is of a healthy man who was diagnosed with acute myeloid leukaemia M5 (monocytic) with trisomy 8 and 11q23 chromosomal translocation. He developed severe skin nodules after cessation of consolidation therapy. He was treated with local radiation and had an excellent response.
中文摘要
粒細胞肉瘤併發嚴重的皮膚病
R Koul, HI Chalchal, A Dubey
急性髓細胞性白血病一般涉及未成熟的髓樣細胞於髓內增生，很少累及髓外。粒細胞肉瘤又稱綠色瘤，是生長於髓外白血病細胞形成腫瘤的一個例子，可以累及身體任何部份。本文報告一名一向健康良好的男子，被確診為急性單核球髓樣白血病M5。他的第八對染色體出現三體症，並於第11對染色體長臂23位置（11q23）有易位。鞏固療法停止後，病人身上出現嚴重的皮膚結節。病人經局部放射治療後，療效良好。