Primary Squamous Cell Carcinoma of the Breast in Two Chinese Women

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TW Chan, AKC Leung, KC Ngan

Hong Kong J Radiol 2012;15:256-9

Primary squamous cell carcinoma of the breast is a rare breast neoplasm. This report describes two Chinese women diagnosed with primary squamous cell carcinoma of the breast. The first patient was a 54-year-old woman with stage pT1cN0M0 triple-negative disease treated with wide local excision and axillary dissection followed by adjuvant chemotherapy with adriamycin and cyclophosphamide, and adjuvant radiotherapy. She was diseasefree on follow-up at 19 months. The second patient was a 63-year-old woman presenting with a 10-cm right breast mass. She was given one cycle of neoadjuvant chemotherapy using docetaxel, cisplatin, and 5-fluorouracil without clinical response. Modified radical mastectomy with transverse rectus abdominis myocutaneous flap was performed. Pathology showed stage pT3N0M0 triple-negative disease. Adjuvant locoregional radiotherapy was given. She was disease-free on follow-up at 19 months. As reported in the literature, squamous cell carcinoma of the breast is mostly triple negative, of large size, and has infrequent nodal involvement at presentation. The disease runs a more aggressive clinical course. There is no consensus on the role and mode of adjuvant treatment. The choice of chemotherapy regimen for this histology remains to be defined.





乳房原發性鱗狀細胞癌是一種罕見的乳腺腫瘤。本文報告乳房原發性鱗狀細胞癌的兩名華藉女性患 者。其中一名被診斷pT1cN0M0期三重陰性乳癌的54歲患者,接受廣泛性局部切除乳房腫瘤及腋下淋 巴切除術,以及術後用adriamycin及cyclophosphamide的輔助化療和輔助放射治療。患者術後19個月 未有復發。另一名63歲患者有10 cm大的腫瘤在右邊乳房。她雖接受docetaxel、cisplatin及5-fluorouracil 的新輔助化療,但臨床未見療效。後接受腹直肌皮瓣的改良型乳房根除手術,病理學發現患者有 pT3N0M0期三重陰性乳癌,遂接受輔助性局部放射治療。患者術後19個月未有復發。文獻中記載大 部份的乳房原發性鱗狀細胞癌病例均為三重陰性、腫瘤偏大,以及病發時很少牽涉淋巴結,這種病 會有侵襲性的臨床病程。對於此病,輔助治療的角色及其形式仍未達至共識,而是否應選擇化療的 方法亦尚有待確定。