Magnetic Resonance Imaging for Chronic Graft-versus-host-disease–related Myositis and Fasciitis: a Rare Complication of Stem Cell Transplantation

Full Article

CYY Kwong, JJK Ip, WWM Lam, MT Chau

Hong Kong J Radiol 2013;16:143-8

DOI: 10.12809/hkjr1312094

Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which is a major cause of morbidity and mortality following allogeneic bone marrow transplantation or stem cell transplantation. Chronic graft-versus-host-disease–related myositis and fasciitis, which have been described as rare complications in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation or stem cell transplantation, can severely impair a patient’s quality of life. This report describes a patient with chronic graft-versus-host-disease–related myositis and fasciitis, and presented with progressive contracture. This report illustrates the imaging features and the role of radiology in the diagnostic process.



慢性移植物抗宿主病相關性肌炎和筋膜炎的磁共振成像: 一種罕見的幹細胞移植併發症


慢性移植物抗宿主病是細胞免疫介導的骨髓移植宿主與病人之間的排斥反應,亦是同種異體骨髓移 植或幹細胞移植致病和死亡的一個主要原因。慢性移植物抗宿主病相關性肌炎和筋膜炎被認為是病 人進行異體骨髓移植或幹細胞移植後的罕見併發症,可嚴重損害患者的生活質素。本文報告一名患 有慢性移植物抗宿主病相關性肌炎和筋膜炎的病例,臨床症狀為進行性關節攣縮。本文闡述了該病 的影像學特徵及影像檢查在診斷過程中的作用。