Radioembolisation of Hepatocellular Carcinoma and Liver Metastases: Imaging Findings Using 90Y Positron Emission Tomography/Computed Tomography and Bremsstrahlung Single Photon Emission Computed Tomography/Computed Tomography

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WH Ma, M Law, WY Ho, KK Wong, S Ng, HY Lau, WK Tso

Hong Kong J Radiol 2014;17:140-4

DOI: 10.12809/hkjr1413199

Radioembolisation with Yttrium-90 (90Y)–labelled microspheres administered via the hepatic artery is currently used to treat primary and metastatic non-resectable liver tumours. 90Y is a pure beta-particle emitter and its energetic beta particle has a range of about 4 mm in soft tissue, making it well suited for treatment of bulky tumours. Bremsstrahlung single photon emission computed tomography/computed tomography (SPECT/CT) is commonly performed to assess the biodistribution of 90Y-labelled microspheres post-radioembolisation. Because 90Y emits positrons in a small percentage of its decays, 90Y positron emission tomography/computed tomography (PET/CT) has recently been used for this purpose, yielding higher-resolution visualisation of the distribution of the microspheres. This pictorial review presents, compares, and contrasts Bremsstrahlung SPECT/CT and PET/CT images post-radioembolisation in four patients treated with 90Y-microspheres.






經肝動脈內注入釔(90Y)微球放療性栓塞目前用於治療無法手術切除的原發性和轉移性肝癌。90Y是一個純β粒子發射器,其高能β粒子的射程在軟組織中約有4 mm,所以適合用於治療大體積的腫瘤。軔致輻射單光子發射電腦斷層/電腦斷層掃描(SPECT/CT)常用於評估放療栓塞後90Y微球的分佈。由於90Y衰變過程中會釋放少量正電子,90Y正電子發射斷層掃描/電腦斷層掃描(PET/CT)最近應用於臨床以得出更高分辨率的微球分佈。本文比較分析四名接受90Y微球放療性栓塞後病人的致輻射SPECT/CT和PET/CT的圖像結果。