Use of NP-59 (131I-iodocholesterol) Scan as a Potential Alternative to Adrenal Venous Sampling in the Investigation of Primary Aldosteronism: a 5-Year Retrospective Study

Full Article

HF Chan, LF Cheng

Hong Kong J Radiol 2014;17:176-81

DOI: 10.12809/hkjr1414230

Objectives: To evaluate the usefulness of NP-59 (131I-iodocholesterol) scan as a non-invasive alternative to adrenal venous sampling in the diagnosis of Conn’s syndrome and lateralisation of aldosterone production.

Methods: The electronic patient records of 39 consecutive patients who were referred for NP-59 scan in our centre between 1 January 2007 and 31 December 2012 were reviewed. The results of NP-59 scan, biochemical test, subsequent treatment plan, histopathology findings, and clinical outcome were evaluated.

Results: Of the 39 patients, 17 had successful lateralisation of aldosterone production by NP-59 scan. Of these 17 patients, 11 had unilateral adrenalectomy, six patients refused surgery. Unilateral adrenalectomy treatment success was reported in all 11 (100%) patients who had lateralisation of aldosterone source by NP-59 scan.

Conclusion: Our study has shown that NP-59 scan as a single imaging investigation has excellent positive predictive value in the diagnosis of aldosterone-producing adenoma (Conn’s syndrome) and NP-59 scan can be used as an alternative to adrenal venous sampling.






目的:探討NP-59(131I-iodocholesterol)掃描作為替代腎上腺靜脈採血的一種非侵入性工具,用於診斷康氏症(Conn’s syndrome)和醛固酮偏側分泌的有效性。