Gefitinib-induced Toxic Epidermal Necrolysis in a Patient with Metastatic Non–small cell Lung Cancer

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L Yang, KO Lam, VHF Lee, AWM Lee

Hong Kong J Radiol 2018;21:e8-11

DOI: 10.12809/hkjr1816416

Toxic epidermal necrolysis (TEN) is a rare acute life-threatening mucocutaneous condition that is usually caused by a reaction to drugs (80-95%). It is characterised by widespread sloughing of the skin and mucosa. Gefitinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is a standard first-line treatment for EGFR-mutated metastatic non–small cell lung cancer. We report a case of TEN complicating gefitinib treatment in a 65-year-old woman with metastatic pulmonary adenocarcinoma. She developed skin eruptions on day 5 of treatment that rapidly evolved to TEN on day 8. This case report highlights the rapidly evolving course of gefitinib-induced TEN and the importance of early diagnosis, prompt withdrawal of the drug, and intensive care.


Author affiliation(s):
L Yang, KO Lam, VHF Lee, AWM Lee: Clinical Oncology Center, University of Hong Kong–Shenzhen Hospital, Shenzhen, China