Characteristic Features of Breast Cancer in Women Aged ≤30 Years

Full Article

JH Lee, CM Kuzmiak, E Cho, YM Park

Hong Kong J Radiol 2019;22:114-22

Objective: To identify and describe the imaging, clinicopathological and biological characteristics of breast cancer for women aged ≤30 years and to correlate the imaging features with clinical and molecular prognostic factors of breast cancer.
Methods: A total of 47 women aged ≤30 years with diagnosed breast cancer were included in this study. The patients’ clinic visit, radiology, and pathology reports were retrospectively reviewed. We analysed the associations between features and outcomes using Fisher’s exact test.
Results: The most common ultrasonographic feature was a mass with suspicious features for malignancy, which was assessed as Breast Imaging-Reporting and Data System (BI-RADS) category 4 (82.2%, 37 / 45) or 5 (17.8%, 8 / 45) in all cases. Of the invasive tumours, 69.0% (29 / 42) had a high histological grade, 61.4% (27 / 44) were oestrogen receptor–positive, 56.8% (25 / 44) were progesterone receptor–positive, and 25.6% (11 / 43) were human epidermal growth factor receptor type 2–positive. There was a significant correlation between mammographic mass margin and BRCA mutation (p = 0.0217); ultrasonographic mass features including margin, echo pattern, posterior feature and hormone receptor status (p = 0.0117-0.0467); and BI-RADS assessment and lymph node metastasis (p = 0.0076). BRCA mutation positive correlated significantly with a high histological grade (p = 0.0243) of tumour.
Conclusion: Breast cancer in women aged ≤30 years more frequently presents as a palpable mass with malignant imaging features and a high histological grade. The imaging and clinical features are significantly associated with prognostic factors of breast cancer in this patient population.


Author affiliation(s):
JH Lee, E Cho: Department of Radiology, Dong-A University College of Medicine, Republic of Korea
CM Kuzmiak: Department of Radiology, University of North Carolina School of Medicine, United States
YM Park: Department of Busan Paik Hospital, Inje University College of Medicine, Republic of Korea





JH Lee、CM Kuzmiak、E Cho、YM Park


結果:最常見的超聲波特徵是具有可疑惡性腫瘤特徵的腫塊。當中屬乳腺影像學報告及數據系統(BI-RADS)第4類佔82.2%(37/45),第5類佔17.8%(8/45)。在浸潤性腫瘤中,69.0%(29/42)屬高組織學級別,61.4%(27/44)的雌激素受體呈陽性,56.8%(25/44)的黃體素受體呈陽性,25.6%(11 / 43)的人類表皮生長因子受體二型呈陽性。乳房X光造影檢查的腫瘤邊緣與BRCA突變(p = 0.0217)、超聲波掃描的腫瘤特徵包括其邊緣、回音模式和腫瘤後部特徵與激素受體狀態(p = 0.0117-0.0467),以及BI-RADS評估與淋巴結轉移(p = 0.0076)均顯著相關。BRCA突變呈陽性與腫瘤的高組織學級別顯著相關(p = 0.0243)。