Leptomeningeal Carcinomatosis of the Spinal Cord Originating from Nasopharyngeal Carcinoma

Full Article

TCY Shum, WT Ng

Hong Kong J Radiol 2013;16:50-4

DOI: 10.12809/hkjr1312111

We report on a 44-year-old man with nasopharyngeal carcinoma with intracranial extension and leptomeningeal metastases in the spinal cord. Marked resolution of the nasopharyngeal carcinoma and leptomeningeal metastases was achieved by using cisplatin-based chemotherapy for six cycles. He was then treated by radiotherapy to residual leptomeningeal metastases at a dose of 30 Gy over 10 fractions, followed by high-dose palliative radiotherapy of 60 Gy over 30 fractions to the nasopharynx and regional lymph nodes. Excellent tumour shrinkage with prolonged survival of more than 1 year was achieved. To the authors’ knowledge, this is the first published report of nasopharyngeal carcinoma resulting in leptomeningeal disease of the spinal cord.

 

中文摘要

一宗鼻咽癌轉移到脊髓軟腦膜的罕見病例

岑翠瑜、吳偉棠

本文報告一名患有鼻咽癌並有顱內及脊髓軟腦膜轉移的44歲男子,病人接受六個療程的順鉑化療 後,鼻咽及軟腦膜腫瘤顯著縮小。其後他繼續接受總劑量為30 Gy分10次針對殘留的軟腦膜轉移灶的 放射治療,然後接受總劑量為60 Gy分30次針對鼻咽部及局部淋巴結的高劑量的姑息性放療。病人腫 瘤灶明顯縮小,生存期延長了一年多。這是文獻中首宗有關鼻咽癌轉移至脊髓軟腦膜的病例報告。