Leptomeningeal Carcinomatosis of the Spinal Cord Originating from Nasopharyngeal Carcinoma

Full Article

TCY Shum, WT Ng

Hong Kong J Radiol 2013;16:50-4

DOI: 10.12809/hkjr1312111

We report on a 44-year-old man with nasopharyngeal carcinoma with intracranial extension and leptomeningeal metastases in the spinal cord. Marked resolution of the nasopharyngeal carcinoma and leptomeningeal metastases was achieved by using cisplatin-based chemotherapy for six cycles. He was then treated by radiotherapy to residual leptomeningeal metastases at a dose of 30 Gy over 10 fractions, followed by high-dose palliative radiotherapy of 60 Gy over 30 fractions to the nasopharynx and regional lymph nodes. Excellent tumour shrinkage with prolonged survival of more than 1 year was achieved. To the authors’ knowledge, this is the first published report of nasopharyngeal carcinoma resulting in leptomeningeal disease of the spinal cord.





本文報告一名患有鼻咽癌並有顱內及脊髓軟腦膜轉移的44歲男子,病人接受六個療程的順鉑化療 後,鼻咽及軟腦膜腫瘤顯著縮小。其後他繼續接受總劑量為30 Gy分10次針對殘留的軟腦膜轉移灶的 放射治療,然後接受總劑量為60 Gy分30次針對鼻咽部及局部淋巴結的高劑量的姑息性放療。病人腫 瘤灶明顯縮小,生存期延長了一年多。這是文獻中首宗有關鼻咽癌轉移至脊髓軟腦膜的病例報告。